OsteoVantage's Osteogenic Spinal Instrumentation Technology
OsteoVantage is developing platform technology that enables the integration of non-pharmacologic, osteo-inductive capabilities into pre-existing implantable instrumentation. Specifically, OsteoVantage’s proprietary system utilizes metal hardware designed for mechanical stabilization and anchoring as the conduit for delivery of osteogenic electrical stimuli in and around the injury site. The first development in OsteoVantage’s product line is the INDOS™ system of osteogenic spinal instrumentation for use in lumbar spinal fusion procedures. The INDOS™ system addresses the clinical need for a simple, integrated system of instrumentation capable of providing spinal stabilization, improving screw retention, and accelerating fusion and improving overall clinical outcomes.
The critical component of the INDOS™ system is the proprietary design of selectively prepared pedicle screws, with unique modification to the threaded screw body that enables induction of therapeutic electrical fields in focused spatial regions around the screw. Manipulation of this pattern modulates the spatial distribution of induced osteogenesis, and further allows for customization of the instrumentation for a variety of anatomical locations and clinical indications.
Preliminary trials demonstrated the efficacy of the INDOS™ osteogenic spinal instrumentation in a large animal model. The concept of using common metallic hardware as a source of osteogenic stimulation was tested utilizing the posterior lumbar interbody fusion (PLIF) technique. Results validated both the potential clinical safety and the efficacy of the novel OV osteogenic spinal instrumentation to induce bone formation in and around instrumented electro-active pedicle screws.
OsteoVantage research focuses on optimizing the instrumentation performance by shaping and directing these fields towards specific regions of interest within the surgical area. The Company applies computational models, capable of evaluating and optimizing the bioelectric properties, as a means of evaluating novel configurations of the integrated pedicle screws that maximize the osteogenic potential in vivo.